These questions form the basis of our work to understand the mechanisms of normal processes and diseases, such as cancer and neuronal degeneration. For this we are using two well-known nematodes (worm) model organisms C. elegans and C. briggsae. These tiny animals (roughly 1 mm long) are particularly useful in discovering the roles of conserved genes and pathways in processes that are shared among all eukaryotes.
Our approach is multidisciplinary and includes techniques in genetics, genomics, molecular biology, bioinformatics, and engineering. We collaborate extensively with other laboratories, both at McMaster and outside, to develop new tools and resources. The applied aspect of our work involves making use of basic research findings and in-house tools to carry out drug discovery projects.
Research projects in our lab are currently funded by the Natural Sciences and Engineering Research Council of Canada (NSERC). In previous years we were also supported by Canadian Institutes of Health Research (CIHR), Ontario Ministry of Research and Innovation (MRI), Canadian Research Chairs (CRC), Canada Foundation for Innovation (CFI), Ontario Innovation Trust (OIT), and National Institutes of Health (NIH).
Please feel free to contact us if you have any questions, comments, and feedback. Thank you!
Department of Biology
Life Sciences Building, Room 322
1280 Main Street West
Hamilton, ON L8S 4K1, CANADA
Phone: 26451 (office) / 23594 (lab)
|@IanDworkin Very nice! All the best. |
About 3 weeks, 1 day ago by: Bhagwati Gupta (@bguptabio)
|RT @Micropub7n: Take note, current microPublication user communities: your submissions to microPublication Biology will now be fully indexe… |
About 3 weeks, 5 days ago by: Bhagwati Gupta (@bguptabio)
|I am excited to share our new manuscript on PRY-1/Axin signalling role in muscle health and #aging #axin… https://t.co/H8w93TzXod |
About 2 months ago by: Bhagwati Gupta (@bguptabio)
|Happy Mother's Day! https://t.co/9HAt6GJx2K |
About 2 months ago by: Bhagwati Gupta (@bguptabio)
|RT @mcmastersgs: Great news for our #McMaster graduate researchers! 830,000 print books from Library’s collection now digitally available o… |
About 2 months, 1 week ago by: Bhagwati Gupta (@bguptabio)
|Excited to be part of this collaborative work with Deen lab! Development of a low-cost, user-customizable, high-spe… https://t.co/jf5ObXvEu3 |
About 2 months ago by: Gupta Lab (@MacWormLab)
|It took many years of work but the paper is finally out!
Evolution of Transcriptional Repressors Impacts Caenorhab… https://t.co/fHIUnOu1mc |
About 2 months, 2 weeks ago by: Gupta Lab (@MacWormLab)
|Read the paper on CRISPR genome editing in C. briggsae published from our lab! https://t.co/BIn1k3w1Ds |
About 4 months, 1 week ago by: Gupta Lab (@MacWormLab)
|A minute of silence on Wednesday for crash victims #BrighterWorld #McMaster https://t.co/I3pOSKj9pm |
About 6 months ago by: Gupta Lab (@MacWormLab)
|RT @bguptabio: Congratulations Sakshi! This is awesome! @MIRAMcMaster #aging https://t.co/gTohpR3Qq3 |
About 7 months ago by: Gupta Lab (@MacWormLab)
Congratulations to all, and keep working hard!
July 3, 2012
Congratulations to Jessica and Justin on winning Ontario Graduate scholarship (OGS) awards!!! In recent years competition is getting increasingly difficult due to fewer awards and more applicants. Therefore it is a huge success for our lab. Well done, Jessica and Justin!
September 23, 2011 [Lab is growing]]
We welcome three new students, Jessica Knox and Justin Tong (both M.Sc.) and Isvarya Venu (undergraduate), who formally joined our lab earlier this month. Jessica and Justin completed undergraduate degrees from McMaster earlier this year. Isvarya is currently in 4th year and will be doing a thesis project. Cheers!
September 23, 2011
Congratulations to Devika and Sangeena for successfully completing transfer exams!!! They are officially Ph.D. candidates now. Celebrations!!!
June 29, 2011 [More on worms…Hamilton Spec news]
Our microfluidics research work has featured in Hamilton Spectator newspaper today! The article describes a novel microfluidics channel setup to study dopamine neuron signalling and neurodegeneration in a C. elegans Parkinson disease model.
Read full story here. Yay!!!!!!
June 27, 2011
Our microfluidics research is featured in McMaster Daily News today! Read it here - Daily News. Keep up the good work guys!
June 26, 2011 [McMaster GSA Travel Award]
Congratulations to Sangeena for receiving the McMaster Graduate Student Association travel grant!!! This will allow her to attend the 18th International Worm Meeting at UCLA. Have fun in La La Land!
June 9, 2011
We welcome the newest member of our lab, Ayush Ranawade, who came to McMaster 3 weeks ago. Ayush was earlier working as a Junior Research Fellow at the National Centre For Biological Sciences (NCBS) in India. He has joined as a M.Sc. student. Cheers!
May 10, 2011
Congratulations to Devika for receiving the 18th International C. elegans Meeting travel grant!!! We wish you all the best in the meeting.
April 9, 2011 [BUS 2011 Award]
Congratulations to Ata Ansari for winning the best presentation award at McMaster Biology Undergraduate Symposium in Genetics section!!! Way to go Ata!
March 11, 2011 [NSERC USRA summer fellowship]
Congratulations to Nayasta for receiving the NSERC USRA 2011 summer research scholarship! This will allow her to study the regulation of lin-39 in worms.