Worm Research Lab

McMaster University

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research [2016/06/01 11:33]
admin [Electrotaxis]
research [2016/06/05 19:11]
admin [Electrotaxis] minor
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 ===== Electrotaxis ===== ===== Electrotaxis =====
  
-{{ :​images:​electrotaxis.gif?​400|}}Our lab is also investigating the electrotaxis phenomenon in nematodes, ​its applications,​ and neuronal basis of such a behavior.\\+{{ :​images:​electrotaxis.gif?​400|}}Our lab is also investigating the electrotaxis phenomenon in nematodes, ​the neuronal basis of this behavior, and its applications.\\
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-**Electrotaxis is the movement of organisms in response to an electric field stimulus.** In collaboration with Ravi Selvaganapathy (Mechanical Engineering,​ McMaster University) <color blue>we provided the first evidence of electrotaxis ​response ​in //C. elegans// in a microfluidic channel environment (Rezai et al., Lab Chip 2010). We showed that DC electric field stimulus ​induces ​the worm to swim towards cathode with a characteristic speed that is robust, instantaneous and highly sensitive.</​color>​ Subsequently,​ we demonstrated that dopamine (DA) neurons play important role in mediating the electrotaxis behavior. The involvement of DA signalling ​has allowed us to model Parkinson'​s disease in //C. elegans//, ​in order to understand ​the mechanism of neurodegeneration and to identify neuorprotective chemicals. ​+**Electrotaxis is the movement of organisms in response to an electric field stimulus.** In collaboration with Ravi Selvaganapathy (Mechanical Engineering,​ McMaster University) <color blue>we provided the first evidence of electrotaxis in //C. elegans// in a microfluidic channel environment (Rezai et al., Lab Chip 2010). We showed that low voltage ​DC electric field induces ​worms to swim towards cathode with a characteristic speed. This response ​is robust, instantaneous and highly sensitive.</​color>​ Subsequently,​ we demonstrated that dopamine (DA) neurons play important role in mediating the electrotaxis behavior. The involvement of DA signalling ​provides a basis to model Parkinson'​s disease in //C. elegans//, ​and to investigate ​the mechanism of neurodegeneration and to identify neuorprotective chemicals. ​
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