The research work in our lab focuses on three fundamental biological questions: how cells respond to external signals (cell signaling), how the timing and number of cell division are controlled (cell proliferation), and how cells acquire unique identities (cell differentiation). These questions form the basis of our work to understand molecular mechanisms of human diseases, such as cancer and neuronal degeneration, and identify potential treatments. For this we are using two well-known nematode (worm) model organisms C. elegans and C. briggsae. These tiny animals (roughly 1 mm long) are particularly useful in discovering the roles of conserved genes and pathways in processes that are shared among all eukaryotes.
Our approach is multidisciplinary and includes techniques in genetics, genomics, molecular biology, bioinformatics, and engineering. We also collaborate with other laboratories, both at McMaster and outside, to develop new tools and resources. The applied aspect of our work involves making use of basic research findings and in-house tools to carry out drug discovery projects.
These projects are funded by Natural Sciences and Engineering Research Council of Canada (NSERC), Canadian Institutes of Health Research (CIHR), and Ontario Ministry of Research and Innovation (MRI). In previous years we were also supported by Canadian Research Chairs (CRC), Canada Foundation for Innovation (CFI), Ontario Innovation Trust (OIT), and National Institutes of Health (NIH).
We hope that the information on this website will help you familiarize with our research projects, team members, and other lab-related activities. Please feel free to email us if you have any questions.